Reduction of the $2.625 trillion USD global food-waste problem is a critical goal in combatting climate change and world hunger. However, the outcome analysis of theoretically 'sustainable' individual biotechnological approaches to food-waste reduction is neglected. This critical review applies the principles of the circular economy to the broader context of biotechnology innovations for food-waste reduction. The evaluation of sustainability and relationship to the food-waste management hierarchy are discussed with relevance to recent innovations in biotransformation of food waste and food-waste prevention. Comparison of these innovation categories reveals the challenges of impact at scale for food-waste reduction biotechnology, particularly in food-waste prevention technologies having low technology-readiness levels, and points to illustrative examples of efforts to meet and overcome these challenges.
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