Utility of Genomic Platforms in Treatment Decisions in Axilla-Positive Breast Cancer

Abstract

Genomic platforms have proven to be more accurate as a prognostic tool than immunohistochemistry studies in patients with early, hormone receptor positive, HER 2 negative breast cancer and, in some cases, have also demonstrated predictive ability for chemotherapy benefit. They are now widely applied in node-negative disease, but their use in node-positive disease is more recent and more controversial, especially in premenopausal patients. In this article, we review the use of these tests in node-positive disease.

Keywords: Genomic platforms, Treatment decisions, Prognostic tool; Luminal breast cancer; Node positive.