Performance of Paracoccus pantotrophus MA3 in heterotrophic nitrification-anaerobic denitrification using formic acid as a carbon source

Bioprocess Biosyst Eng. 2022 Oct;45(10):1661-1672. doi: 10.1007/s00449-022-02771-3. Epub 2022 Aug 19.

Abstract

Excess amount of nitrogen in wastewater has caused serious concerns, such as water eutrophication. Paracoccus pantotrophus MA3, a novel isolated strain of heterotrophic nitrification-anaerobic denitrification bacteria, was evaluated for nitrogen removal using formic acid as the sole carbon source. The results showed that the maximum ammonium removal efficiency was observed under the optimum conditions of 26.25 carbon to nitrogen ratio, 3.39% (v/v) inoculation amount, 34.64 °C temperature, and at 180 rpm shaking speed, respectively. In addition, quantitative real-time PCR technique analysis assured that the gene expression level of formate dehydrogenase, formate tetrahydrofolate ligase, 5,10-methylenetetrahydrofolate dehydrogenase, serine hydroxymethyltransferase, respiratory nitrate reductase beta subunit, L-glutamine synthetase, glutamate dehydrogenase, and glutamate synthase were up-regulated compared to the control group, and combined with nitrogen mass balance analysis to conclude that most of the ammonium was removed by assimilation. A small amount of nitrate and nearly no nitrite were accumulated during heterotrophic nitrification. MA3 exhibited significant denitrification potential under anaerobic conditions with a maximum nitrate removal rate of 4.39 mg/L/h, and the only gas produced was N2. Additionally, 11.50 ± 0.06 mg/L/h of NH4+-N removal rate from biogas slurry was achieved.

Keywords: Ammonium removal; Heterotrophic nitrification–anaerobic denitrification; Paracoccus pantotrophus; Response surface methodology (RSM); qRT-PCR.

MeSH terms

  • Aerobiosis
  • Ammonium Compounds* / metabolism
  • Anaerobiosis
  • Biofuels
  • Carbon
  • Denitrification
  • Formate Dehydrogenases / metabolism
  • Formate-Tetrahydrofolate Ligase* / metabolism
  • Formates
  • Glutamate Dehydrogenase
  • Glutamate Synthase / metabolism
  • Glutamate-Ammonia Ligase / metabolism
  • Glycine Hydroxymethyltransferase / metabolism
  • Methylenetetrahydrofolate Dehydrogenase (NADP) / metabolism
  • Nitrate Reductase / metabolism
  • Nitrates / metabolism
  • Nitrification
  • Nitrogen / metabolism
  • Paracoccus pantotrophus* / metabolism
  • Wastewater
  • Water

Substances

  • Ammonium Compounds
  • Biofuels
  • Formates
  • Nitrates
  • Waste Water
  • Water
  • formic acid
  • Carbon
  • Formate Dehydrogenases
  • Glutamate Synthase
  • Glutamate Dehydrogenase
  • Methylenetetrahydrofolate Dehydrogenase (NADP)
  • Nitrate Reductase
  • Glycine Hydroxymethyltransferase
  • Glutamate-Ammonia Ligase
  • Formate-Tetrahydrofolate Ligase
  • Nitrogen