A brief overview about the adipokine: Isthmin-1

Min Hu; Xin Zhang; Can Hu; Teng Teng; Qi-Zhu Tang

doi:10.3389/fcvm.2022.939757

A brief overview about the adipokine: Isthmin-1

Front Cardiovasc Med. 2022 Jul 26:9:939757. doi: 10.3389/fcvm.2022.939757. eCollection 2022.

Authors

Min Hu^{1

2}, Xin Zhang^{1

2}, Can Hu^{1

2}, Teng Teng^{1

2}, Qi-Zhu Tang^{1

2}

Affiliations

¹ Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
² Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, China.

Abstract

Isthmin-1 is a secreted protein with multiple capability; however, it truly attracts our attention since the definition as an adipokine in 2021, which exerts indispensable roles in various pathophysiological processes through the endocrine or autocrine manners. In this review, we summarize recent knowledge of isthmin-1, including its distribution, structure, receptor and potential function.

Keywords: adipokine; biological function; distribution; isthmin-1; receptor; structure.

Publication types

Review