Prevention and treatment of natural products from Traditional Chinese Medicine in depression: Potential targets and mechanisms of action

Ming-Chao He; Rui Feng; Jing Wang; Shi-Hui Xia; Yong-Jun Wang; Yan Zhang

doi:10.3389/fnagi.2022.950143

Prevention and treatment of natural products from Traditional Chinese Medicine in depression: Potential targets and mechanisms of action

Front Aging Neurosci. 2022 Jul 18:14:950143. doi: 10.3389/fnagi.2022.950143. eCollection 2022.

Authors

Ming-Chao He¹, Rui Feng¹, Jing Wang², Shi-Hui Xia¹, Yong-Jun Wang¹, Yan Zhang¹

Affiliations

¹ Spine Disease Research Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
² Shanghai Geriatric Institute of Chinese Medicine, Shanghai, China.

Abstract

The molecular pathology involved in the development of depression is complex. Many signaling pathways and transcription factors have been demonstrated to display crucial roles in the process of depression occurrence and development. The multi-components and multi-targets of Traditional Chinese Medicine (TCM) are uniquely advantageous in the prevention and treatment of chronic diseases. This review summarizes the pharmacological regulations of natural products from TCM in the prevention and treatment of depression from the aspects of transcription factors (CREB, NF-κB, Nrf2) and molecular signaling pathways (BDNF-TrkB, MAPK, GSK-3β, TLR-4).

Keywords: Traditional Chinese Medicine; action target; depression; signaling pathway; transcription factor.

Publication types

Review