Aim: aim of the study was to evaluate serum short chain fatty acids (SCFA) concentrations in patients with Type 2 diabetes (T2D) and overweight/obese individuals.
Methods: In forty-three patients with T2D and twenty-eight overweight/obese patients SCFA were determined by Gas-Chromatography/Flame Ionization Detector (GC/FID).
Results: Acetic acid, propionic acid, butyric acid, and total SCFA were significantly reduced in T2D patients compared to overweight/obese in the unadjusted model. Adjusting for all variables only propionic acid remained significantly lower in T2D.
Conclusion: Only reduction of propionic acid was closely related to diabetes itself, regardless of all other factors.
Keywords: Gut microbiota; Obesity; Short-chain fatty acids; Type 2 diabetes.
© 2022. Springer-Verlag Italia S.r.l., part of Springer Nature.