A tRF nucleator for Nucleolin in cancer metastasis

Mol Cell. 2022 Jul 21;82(14):2536-2538. doi: 10.1016/j.molcel.2022.06.025.

Abstract

In this issue of Molecular Cell, Liu et al. (2022) report that 5'-tRFCys, a stress-induced transfer RNA-derived RNA fragment (tRF) derived from the 5' halves of cysteine tRNAs, regulates post-transcriptional gene expression, enabling the survival and lung metastasis formation of breast cancers.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Breast Neoplasms* / genetics
  • Female
  • Humans
  • Nucleolin
  • Phosphoproteins / genetics
  • Phosphoproteins / metabolism
  • RNA, Transfer / genetics
  • RNA, Transfer / metabolism
  • RNA-Binding Proteins* / genetics
  • RNA-Binding Proteins* / metabolism

Substances

  • Phosphoproteins
  • RNA-Binding Proteins
  • RNA, Transfer