Exploring the Reaction Mechanism of C-H Oxidation by Copper-Salen Complexes

J Phys Chem A. 2022 Aug 4;126(30):4969-4980. doi: 10.1021/acs.jpca.2c03344. Epub 2022 Jul 21.

Abstract

The mechanism of C-H oxidation of propylene (C3H6) and 1-phenyl-1-pentyne (C3H7-C≡C-Ph) by HOOR (R═Me, tBu) and 3O2 by a copper-salen complex was explored by computations. The most noteworthy step is the complexation of two Cu salens to the peroxide to form either the LCuOH/LCuOR pair or an OH-bridged complex LCu(μ-OH)CuL plus OR. The latter pathway involves an avoided crossing of two triplet electronic states. The LCuOH complex can abstract a hydrogen atom from C3H6 and the C3H5 radical plus 3O2 forms the complex LCuOOC3H5. Migration of a hydrogen to the proximal oxygen atom reforms LCuOH and acrolein HC(O)CH═CH2.

MeSH terms

  • Copper* / chemistry
  • Ethylenediamines*
  • Hydrogen
  • Oxidation-Reduction
  • Oxygen / chemistry

Substances

  • Ethylenediamines
  • Copper
  • Hydrogen
  • disalicylaldehyde ethylenediamine
  • Oxygen