Linalool Impress Colorectal Cancer Deterioration by Mediating AKT/mTOR and JAK2/STAT3 Signaling Pathways

Biomed Res Int. 2022 Jul 11:2022:4801703. doi: 10.1155/2022/4801703. eCollection 2022.

Abstract

Colorectal cancer (CRC) is one of the more common causes of cancer death worldwide. Chemotherapy is effective in the treatment of CRC, but it can produce a range of adverse effects that can significantly reduce the quality of life of CRC patients. The selection of drugs that are effective in treating CRC with few adverse effects is now an important task and is aimed at prolonging the survival of patients and improving their prognosis. In this study, CRC cells were treated with linalool using CRC cell lines as the study subjects, and cell viability, apoptosis, and cell migration were observed after treatment. Previous studies have demonstrated the therapeutic effects of linalool on CRC and its ability to inhibit CRC progression by modulating the AKT/mTOR and JAK2/STAT3 pathways.

Publication types

  • Retracted Publication

MeSH terms

  • Acyclic Monoterpenes
  • Apoptosis
  • Cell Line, Tumor
  • Cell Proliferation
  • Colorectal Neoplasms* / drug therapy
  • Colorectal Neoplasms* / metabolism
  • Humans
  • Janus Kinase 2 / metabolism
  • Proto-Oncogene Proteins c-akt* / metabolism
  • Quality of Life
  • STAT3 Transcription Factor / metabolism
  • Signal Transduction
  • TOR Serine-Threonine Kinases / metabolism

Substances

  • Acyclic Monoterpenes
  • STAT3 Transcription Factor
  • STAT3 protein, human
  • linalool
  • MTOR protein, human
  • JAK2 protein, human
  • Janus Kinase 2
  • Proto-Oncogene Proteins c-akt
  • TOR Serine-Threonine Kinases