Reeling it in: how DNA topology drives loop extrusion by condensin

Domenic N Narducci; Anders S Hansen

doi:10.1038/s41594-022-00805-8

Reeling it in: how DNA topology drives loop extrusion by condensin

Nat Struct Mol Biol. 2022 Jul;29(7):623-625. doi: 10.1038/s41594-022-00805-8.

Authors

Domenic N Narducci^{1

2}, Anders S Hansen^{3

4}

Affiliations

¹ Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
² The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
³ Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. ashansen@mit.edu.
⁴ The Broad Institute of MIT and Harvard, Cambridge, MA, USA. ashansen@mit.edu.

Abstract

Structural maintenance of chromosomes (SMC) complexes such as condensin regulate chromosome organization by extruding loops. A new study uses single-molecule imaging of condensin on supercoiled DNA to understand how condensins navigate the under- and overwound DNA states common throughout the genome.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Adenosine Triphosphatases* / genetics
Cell Cycle Proteins / genetics
Chromosomes
DNA
DNA-Binding Proteins / genetics
Multiprotein Complexes* / genetics

Substances

Cell Cycle Proteins
DNA-Binding Proteins
Multiprotein Complexes
condensin complexes
DNA
Adenosine Triphosphatases

Abstract

Publication types

MeSH terms

Substances

Grants and funding