Since the discovery of circulating hepatitis B virus (HBV) RNA in the peripheral blood of patients with chronic hepatitis B in 1996, a growing number of studies have focused on clarifying the biological characteristics and clinical application value of serum HBV RNA. This consensus mainly summarizes the research progress of serum HBV RNA existing profiles, quantitative detection methods, and current clinical applications. In order to better apply this indicator for the clinical management of patients with chronic HBV infection, recommendations on quantitative detection target regions, detection results, and clinical applications are put forward.
自1996年在慢性乙型肝炎患者的外周血中发现游离的乙型肝炎病毒（HBV）RNA以来，越来越多的研究致力于阐明血清HBV RNA的生物学特征和临床应用价值。该共识总结了血清HBV RNA存在形式、定量检测方法及目前临床应用的研究进展，并针对定量检测的靶标区域、检测结果和临床应用作出推荐意见，以期更好地将该指标用于临床慢性HBV感染者的管理。.