An adaptive platform trial for evaluating treatments in patients with life-threatening hemorrhage from traumatic injuries: Ethical and US regulatory considerations

Affiliations

• ¹ Goldkind Consulting, LLC, Chevy Chase, Maryland, USA.
• ² Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
• ³ Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance, California, USA.
• ⁴ Department of Emergency Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
• ⁵ Berry Consultants, LLC, Austin, Texas, USA.
• ⁶ Department of Pediatrics, McGovern Medical School at UT Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
• ⁷ Department of Surgery and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
• ⁸ Joint Trauma System, Defense Health Agency, Joint Base San Antonio Fort Sam Houston, Fort Sam Houston, Texas, USA.
• ⁹ Department of Surgery, Division of Acute Care Surgery, Center for Injury Science, University of Alabama at Birmingham, Birmingham, Alabama, USA.