ROS-responsive copolymer micelles for inflammation triggered delivery of ibuprofen

Jing Yang Quek; Richard Bright; Prl Dabare; Krasimir Vasilev

doi:10.1016/j.colsurfb.2022.112590

ROS-responsive copolymer micelles for inflammation triggered delivery of ibuprofen

Colloids Surf B Biointerfaces. 2022 Sep:217:112590. doi: 10.1016/j.colsurfb.2022.112590. Epub 2022 May 23.

Authors

Jing Yang Quek¹, Richard Bright², Prl Dabare³, Krasimir Vasilev⁴

Affiliations

¹ UniSA STEM, University of South Australia, Mawson Lakes, South Australia 5095, Australia. Electronic address: ray.quek@unisa.edu.au.
² UniSA STEM, University of South Australia, Mawson Lakes, South Australia 5095, Australia.
³ UniSA STEM, University of South Australia, Mawson Lakes, South Australia 5095, Australia; College of Medicine and Public Health, Flinders University, Sturt Road, Bedford Park, South Australia 5042, Australia.
⁴ UniSA STEM, University of South Australia, Mawson Lakes, South Australia 5095, Australia; College of Medicine and Public Health, Flinders University, Sturt Road, Bedford Park, South Australia 5042, Australia. Electronic address: krasimir.vasilev@unisa.edu.au.

PMID: 35660744
DOI: 10.1016/j.colsurfb.2022.112590

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for the treatment of pain, inflammation and fever. However, most NSAIDs are poorly water soluble, making it difficult to be administered thus high doses are required to reach the intended therapeutic effect, resulting in associated side effects. In this study, ROS-responsive micellar systems based on a block copolymer consisting of methylpropyl thioether (MTPA) and N'N-dimethylacrylamide was developed and loaded with ibuprofen (IBU). Using lipopolysaccharide activated RAW 264.7 macrophage like cells, we demonstrated that IBU was released from the copolymer, specifically in the presence of ROS. Interestingly, IBU encapsulated in ROS-responsive nanoparticles exhibited greater anti-inflammatory potency compared to its free form. The work highlights the potential of the ROS-responsive micellar system developed in this work to be used as carrier of NSAIDs for the treatment of relevant inflammatory conditions.

Keywords: Anti-inflammatory; Ibuprofen; Inflammation triggered drug delivery; Polymeric micelles; ROS-responsive.

MeSH terms

Anti-Inflammatory Agents, Non-Steroidal / pharmacology
Humans
Ibuprofen* / pharmacology
Inflammation / chemically induced
Inflammation / drug therapy
Micelles*
Polymers
Reactive Oxygen Species

Substances

Anti-Inflammatory Agents, Non-Steroidal
Micelles
Polymers
Reactive Oxygen Species
Ibuprofen