Phytochemically stabilized chitosan encapsulated Cu and Ag nanocomposites to remove cefuroxime axetil and pathogens from the environment

Abstract

Antibiotics have been a source of concern since they are causing resistance in bacteria that live in water and air. As a result, green technology was used to manufacture silver and copper nanoparticles, which were encapsulated with the biopolymer chitosan derived from the root extract of the Potentilla astrosanguinea plant. XRD, FTIR, TEM, EDX, and UV-Visible spectroscopy were methods used for structural and spectroscopic analysis. These nanomaterials have a roughly spherical 2-30 nm average size and a face-centered cubic (FCC) shape, according to the findings. The photocatalytic drug degradation and antibacterial properties of the produced nanocomposites were outstanding, with some resistance lasting longer than 180 days. The current study discovered that under UV light exposure, silver nanocomposites degrade drugs rapidly within 40 min, with an average rate of over 95%, while copper nanocomposites degrade drugs rapidly within 70 min, with an average rate of 84%. These nanocomposites have demonstrated exceptionally compelling antibacterial action against Gram-positive, Gram-negative, and fungal pathogens in addition to photocatalytic activity. The lowest recorded MIC values were 10.30 μg/mL and 10.84 μg/mL, respectively, whereas the lowest MBC values were 91.24 μg/mL and 99.50 μg/mL.

Keywords: Antimicrobial activity; Biopolymer; Photocatalytic drug degradation; Phytochemical.