Rapid Access to Aliphatic Sulfonamides

Org Lett. 2022 Jun 10;24(22):3932-3937. doi: 10.1021/acs.orglett.2c01236. Epub 2022 May 26.

Abstract

Herein, we report a mild, rapid, straightforward method for visible-light-mediated sulfonamide ethylation to afford a diverse array of compounds with C(sp3)-sulfonamide skeletons. The method relies on inexpensive, abundant, commercially available primary, secondary, and tertiary alkyl carboxylic acids and alkyl iodides as substrates. The method has a broad substrate scope and potential utility for late-stage functionalization of natural products and synthetic medicines and can be expected to facilitate rapid structural diversification of bioactive molecules.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carboxylic Acids* / chemistry
  • Catalysis
  • Light
  • Sulfonamides* / chemistry

Substances

  • Carboxylic Acids
  • Sulfonamides