UPF1 adds an m6A feather to its (de)cap

Michelle R Gibbs; Guillaume F Chanfreau

doi:10.1016/j.celrep.2022.110898

UPF1 adds an m⁶A feather to its (de)cap

Cell Rep. 2022 May 24;39(8):110898. doi: 10.1016/j.celrep.2022.110898.

Authors

Michelle R Gibbs¹, Guillaume F Chanfreau²

Affiliations

¹ Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095-1569, USA.
² Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095-1569, USA. Electronic address: guillom@chem.ucla.edu.

PMID: 35613576
DOI: 10.1016/j.celrep.2022.110898

Abstract

The N⁶-methyladenosine modification (m⁶A) modulates eukaryotic mRNA decay. In this issue of Cell Reports, Boo et al. describe a mechanism for degradation of m⁶A-containing mRNAs by 5'-decapping, which occurs through the recruitment of the degradation factor UPF1 via the m⁶A reader protein YTHDF2.

MeSH terms

Adenosine* / metabolism
Animals
Feathers / metabolism
RNA Stability / genetics
RNA, Messenger / genetics
RNA, Messenger / metabolism
RNA-Binding Proteins* / genetics
RNA-Binding Proteins* / metabolism

Substances

RNA, Messenger
RNA-Binding Proteins
Adenosine

Grants and funding

R35 GM130370/GM/NIGMS NIH HHS/United States