First Reported Case of Atypical Meningioma in an Individual with Down Syndrome

Rachel Vanderschelden; Kiarash Golshani; Mark G Evans

doi:10.1159/000523665

First Reported Case of Atypical Meningioma in an Individual with Down Syndrome

Case Rep Neurol. 2022 Apr 4;14(1):191-196. doi: 10.1159/000523665. eCollection 2022 Jan-Apr.

Authors

Rachel Vanderschelden¹, Kiarash Golshani², Mark G Evans³

Affiliations

¹ Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
² Department of Neurological Surgery, University of California Irvine, Orange, California, USA.
³ Division of Pathology and Laboratory Medicine, Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Abstract

Individuals with Down syndrome are at decreased risk of developing most types of solid tumors, including central nervous system malignancies. Several mechanisms have been proposed to explain how additional genetic material on chromosome 21 may confer this increased protection. Only two individuals with Down syndrome and meningioma have been described in the medical literature, whose tumors were both World Health Organization (WHO) grade 1. Here, we report the first individual with Down syndrome to our knowledge who developed an atypical meningioma, WHO grade 2. We also provide a hypothesis for how this tumor could have arisen in the setting of trisomy 21.

Keywords: Atypical meningioma; Down syndrome; Trisomy 21.

Publication types

Case Reports