A new Down syndrome rat model races forward

Randall J Roper; Charles R Goodlett

doi:10.1016/j.tig.2022.05.001

A new Down syndrome rat model races forward

Trends Genet. 2022 Nov;38(11):1101-1102. doi: 10.1016/j.tig.2022.05.001. Epub 2022 May 15.

Authors

Randall J Roper¹, Charles R Goodlett²

Affiliations

¹ Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA. Electronic address: rjroper@iupui.edu.
² Department of Psychology, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA; Graduate Program in Addiction Neuroscience, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA.

Abstract

Animal models of Down syndrome (DS) provide an essential resource for understanding genetic, cellular, and molecular contributions to traits associated with trisomy 21 (Ts21). Recent genetic enhancements in the development of DS models, including the new TcHSA21rat model (Kazuki et al.), have potential to transform our understanding of and potential therapies for Ts21.

Keywords: animal models; gene dosage; gene expression; neurodevelopment; trisomy.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Animals
Disease Models, Animal
Down Syndrome* / genetics
Phenotype
Rats

Abstract

Publication types

MeSH terms

Grants and funding