A novel ratiometric fluorescent probe for rapid detection of hydrogen peroxide in living cells

Linan Hu; Jiayi Liu; Jie Zhang; Hailiang Zhang; Pengfei Xu; Zhu Chen; Enhua Xiao

doi:10.1039/c9ra07517h

A novel ratiometric fluorescent probe for rapid detection of hydrogen peroxide in living cells

RSC Adv. 2019 Dec 2;9(67):39532-39535. doi: 10.1039/c9ra07517h. eCollection 2019 Nov 27.

Authors

Linan Hu^{1

2}, Jiayi Liu¹, Jie Zhang¹, Hailiang Zhang³, Pengfei Xu³, Zhu Chen¹, Enhua Xiao¹

Affiliations

¹ Departments of Radiology, The Second Xiangya Hospital, Central South University Changsha Hunan 410011 P. R. China.
² Departments of Radiology, Zhuzhou Central Hospital Zhuzhou Hunan 412000 P. R. China.
³ Institute of Clinical Pharmacy & Pharmacology, Jining First People's Hospital, Jining Medical University Jining 272000 P. R. China.

Abstract

In this work, we present a new ratiometric fluorescent probe JNY-1 for rapid and convenient detection of H₂O₂. The probe could selectively and sensitively respond to H₂O₂ within 10 min. In addition, this probe was successfully applied for monitoring and imaging of H₂O₂ in liver cancer HepG2 cells under physiological conditions.