Biomedical polymers: synthesis, properties, and applications

Wei-Hai Chen; Qi-Wen Chen; Qian Chen; Chunyan Cui; Shun Duan; Yongyuan Kang; Yang Liu; Yun Liu; Wali Muhammad; Shiqun Shao; Chengqiang Tang; Jinqiang Wang; Lei Wang; Meng-Hua Xiong; Lichen Yin; Kuo Zhang; Zhanzhan Zhang; Xu Zhen; Jun Feng; Changyou Gao; Zhen Gu; Chaoliang He; Jian Ji; Xiqun Jiang; Wenguang Liu; Zhuang Liu; Huisheng Peng; Youqing Shen; Linqi Shi; Xuemei Sun; Hao Wang; Jun Wang; Haihua Xiao; Fu-Jian Xu; Zhiyuan Zhong; Xian-Zheng Zhang; Xuesi Chen

doi:10.1007/s11426-022-1243-5

Biomedical polymers: synthesis, properties, and applications

Sci China Chem. 2022;65(6):1010-1075. doi: 10.1007/s11426-022-1243-5. Epub 2022 Apr 24.

Authors

Wei-Hai Chen¹, Qi-Wen Chen¹, Qian Chen², Chunyan Cui³, Shun Duan⁴, Yongyuan Kang⁵, Yang Liu⁶, Yun Liu^{7

8}, Wali Muhammad⁵, Shiqun Shao^{9

10}, Chengqiang Tang¹¹, Jinqiang Wang^{7

8}, Lei Wang¹², Meng-Hua Xiong¹³, Lichen Yin¹⁴, Kuo Zhang¹², Zhanzhan Zhang⁶, Xu Zhen¹⁵, Jun Feng¹, Changyou Gao⁵, Zhen Gu^{7

8}, Chaoliang He¹⁶, Jian Ji⁵, Xiqun Jiang¹⁵, Wenguang Liu³, Zhuang Liu², Huisheng Peng¹¹, Youqing Shen^{9

10}, Linqi Shi⁶, Xuemei Sun¹¹, Hao Wang¹², Jun Wang¹³, Haihua Xiao¹⁷, Fu-Jian Xu⁴, Zhiyuan Zhong^{18

19}, Xian-Zheng Zhang¹, Xuesi Chen¹⁶

Affiliations

¹ Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan, 430072 China.
² Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, 215123 China.
³ School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, 300350 China.
⁴ Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology), Ministry of Education, Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029 China.
⁵ MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027 China.
⁶ State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials of Ministry of Education, College of Chemistry, Nankai University, Tianjin, 300071 China.
⁷ Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China.
⁸ Jinhua Institute of Zhejiang University, Jinhua, 321299 China.
⁹ Zhejiang Key Laboratory of Smart BioMaterials and Center for Bionanoengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027 China.
¹⁰ ZJU-Hangzhou Global Scientific and Technological Innovation Center, Hangzhou, 311215 China.
¹¹ State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science and Laboratory of Advanced Materials, Fudan University, Shanghai, 200438 China.
¹² CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nano-science, National Center for Nanoscience and Technology (NCNST), Beijing, 100190 China.
¹³ School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou, 510006 China.
¹⁴ Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Collaborative Innovation Center of Suzhou Nano Science & Technology, Soochow University, Suzhou, 215123 China.
¹⁵ Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093 China.
¹⁶ CAS Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China.
¹⁷ Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190 China.
¹⁸ Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, 215123 China.
¹⁹ College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123 China.

Abstract

Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation.

Keywords: biocompatibility; bioimaging and biosensing; biomedical polymer; cancer therapy; cytotoxicity; drug delivery; nanomedicine; regenerative medicine; tissue engineering.

Publication types

Review