Shared sugars - parasite glycan homology in HIV-1 vaccine design

Trends Parasitol. 2022 Jul;38(7):498-500. doi: 10.1016/j.pt.2022.04.001. Epub 2022 Apr 29.

Abstract

Immune tolerance to self-glycans is a host mechanism to avoid autoimmunity, which is exploited by HIV-1 coating its envelope glycoproteins with glycans to evade neutralising antibodies (nAbs). Huettner et al. describe cross-reactivity between Schistosoma mansoni glycans and HIV-1 envelope glycoprotein glycans, suggesting a strategy for induction of HIV-1 nAbs by vaccination.

Keywords: HIV-1; antibody; glycan; helminth; parasite.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • HIV-1*
  • Parasites*
  • Polysaccharides
  • Sugars
  • Vaccines*

Substances

  • Polysaccharides
  • Sugars
  • Vaccines