A 'NAC' for targeting proteins to the ER

João P L Coelho; Sichen Shao

doi:10.1016/j.tibs.2022.04.007

A 'NAC' for targeting proteins to the ER

Trends Biochem Sci. 2022 Sep;47(9):730-731. doi: 10.1016/j.tibs.2022.04.007. Epub 2022 Apr 29.

Authors

João P L Coelho¹, Sichen Shao²

Affiliations

¹ Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
² Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA. Electronic address: sichen_shao@hms.harvard.edu.

PMID: 35501234
DOI: 10.1016/j.tibs.2022.04.007

Abstract

The signal recognition particle (SRP) cotranslationally targets a large and diverse portion of the nascent proteome to the endoplasmic reticulum (ER). A recent study by Jomaa et al. reveals an unexpected function for the ribosome-bound nascent chain-associated complex (NAC) in sensing ER-targeting signals and recruiting SRP to the appropriate ribosomes for high-fidelity targeting.

Publication types

Comment

MeSH terms

Endoplasmic Reticulum* / metabolism
Protein Biosynthesis
Ribosomes / metabolism
Signal Recognition Particle* / metabolism

Substances

Signal Recognition Particle

Abstract

Publication types

MeSH terms

Substances

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