Double Trouble: Whole-Genome Doubling Distinguishes Early from Late Ovarian Cancer

Shih Yu Cindy Yang; Trevor J Pugh; Amit M Oza

doi:10.1158/1078-0432.CCR-22-0336

Double Trouble: Whole-Genome Doubling Distinguishes Early from Late Ovarian Cancer

Clin Cancer Res. 2022 Jul 1;28(13):2730-2732. doi: 10.1158/1078-0432.CCR-22-0336.

Authors

Shih Yu Cindy Yang¹, Trevor J Pugh^{1

2

3}, Amit M Oza^{1

4

5}

Affiliations

¹ Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.
² Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
³ Department of Genomics, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
⁴ Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.
⁵ Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

Abstract

Dramatic differences in outcome between early- and late-stage high-grade serous ovarian cancer (HGSC) suggest perhaps distinct genetic origins due to differences in exposures to mutational processes. Evidence to support this hypothesis was recently reported by comparative analysis of copy-number signatures between early- and late-stage HGSCs. See related article by Cheng et al., p. 2911.

Publication types

Editorial
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Carcinoma, Ovarian Epithelial
Cystadenocarcinoma, Serous* / diagnosis
Cystadenocarcinoma, Serous* / genetics
Cystadenocarcinoma, Serous* / pathology
Fallopian Tube Neoplasms* / genetics
Fallopian Tube Neoplasms* / pathology
Female
Genomics
Humans
Ovarian Neoplasms* / diagnosis
Ovarian Neoplasms* / genetics
Ovarian Neoplasms* / pathology