Surgical Neuro-Oncology: Management of Glioma

Dana Mitchell; Jack M Shireman; Mahua Dey

doi:10.1016/j.ncl.2021.11.003

Surgical Neuro-Oncology: Management of Glioma

Neurol Clin. 2022 May;40(2):437-453. doi: 10.1016/j.ncl.2021.11.003. Epub 2022 Mar 31.

Authors

Dana Mitchell¹, Jack M Shireman², Mahua Dey³

Affiliations

¹ Department of Pediatrics, Indiana University, Herman B. Wells Center for Pediatric Research 1044 W Walnut St, Indianapolis, IN 46202, USA.
² Department of Neurosurgery, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue CSC K3/803, Madison, WI 53792, USA.
³ Department of Neurosurgery, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue CSC K3/803, Madison, WI 53792, USA. Electronic address: dey@neurosurgery.wisc.edu.

Abstract

Gliomas are the most common intrinsic brain tumor in adults. Although maximal tumor resection improves survival, this must be balanced with preservation of neurologic function. Technological advancements have greatly expanded our ability to safely maximize tumor resection and design innovative therapeutic trials that take advantage of intracavitary delivery of therapeutic agents after resection. In this article, we review the role of surgical intervention for both low-grade and high-grade gliomas and the innovations that are driving and expanding the role of surgery in this therapeutically challenging group of malignancies.

Keywords: Astrocytoma; Biopsy; Glioblastoma; Glioma; Low-grade glioma; Management; Oligodendroglioma; Surgery.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Adult
Brain Neoplasms* / pathology
Brain Neoplasms* / surgery
Glioma* / surgery
Humans

Grants and funding

K08 NS092895/NS/NINDS NIH HHS/United States