Abstract
Drug induced toxic epidermal necrolysis and Stevens-Johnson syndrome are weakly associated with HLA-B12. Among patients reacting to a given drug we observed stronger links, especially for HLA-A29; B12; DR7 and sulphonamides.
MeSH terms
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Adolescent
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Adult
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Aged
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects
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Child
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Disease Susceptibility
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Female
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HLA Antigens / analysis*
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HLA Antigens / genetics
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HLA-A Antigens*
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HLA-B Antigens*
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HLA-DR Antigens / genetics
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HLA-DR7 Antigen
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Humans
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Male
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Middle Aged
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Phenotype
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Skin Diseases, Vesiculobullous / chemically induced*
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Skin Diseases, Vesiculobullous / immunology
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Stevens-Johnson Syndrome / chemically induced
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Stevens-Johnson Syndrome / immunology
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Sulfonamides / adverse effects
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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HLA Antigens
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HLA-A Antigens
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HLA-A29 antigen
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HLA-B Antigens
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HLA-B12 antigen
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HLA-DR Antigens
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HLA-DR7 Antigen
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Sulfonamides