A single bacterial enzyme i(NHI)bits phage DNA replication

Erin Huiting; Joseph Bondy-Denomy

doi:10.1016/j.chom.2022.03.025

A single bacterial enzyme i(NHI)bits phage DNA replication

Cell Host Microbe. 2022 Apr 13;30(4):417-419. doi: 10.1016/j.chom.2022.03.025.

Authors

Erin Huiting¹, Joseph Bondy-Denomy²

Affiliations

¹ Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA.
² Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA; Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA 94158, USA; Innovative Genomics Institute, Berkeley, CA 94720, USA. Electronic address: Joseph.Bondy-Denomy@ucsf.edu.

PMID: 35421333
DOI: 10.1016/j.chom.2022.03.025

Abstract

In this issue of Cell Host & Microbe, Nayeemul Bari et al. discover an anti-phage immune system in bacteria that uses a single enzyme to accomplish the challenging feat of detecting phage DNA and limiting its replication. Unlike CRISPR-Cas and restriction modification (R-M) systems, which use sequence motifs, nuclease-helicase immunity (Nhi) is proposed to target phage-specific replication intermediates.

Publication types

Comment

MeSH terms

Bacteria / genetics
Bacteriophages* / genetics
CRISPR-Cas Systems
DNA Helicases / genetics
DNA Replication

Substances

DNA Helicases

Abstract

Publication types

MeSH terms

Substances

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