Synthesis and Characterization of an Inclusion Complex of dl-Aminoglutethimide with β-Cyclodextrin and Its Innovative Application in a Biological System: Computational and Experimental Investigations

Samapika Ray; Niloy Roy; Biraj Kumar Barman; Paramita Karmakar; Pranish Bomzan; Biplab Rajbanshi; Vikas Kumar Dakua; Ankita Dutta; Anoop Kumar; Mahendra Nath Roy

doi:10.1021/acsomega.2c00011

Synthesis and Characterization of an Inclusion Complex of dl-Aminoglutethimide with β-Cyclodextrin and Its Innovative Application in a Biological System: Computational and Experimental Investigations

ACS Omega. 2022 Mar 28;7(13):11208-11216. doi: 10.1021/acsomega.2c00011. eCollection 2022 Apr 5.

Authors

Affiliations

¹ University of North Bengal, Department of Chemistry, Raja Rammohanpur, Darjeeling, West Bengal, India 734013.
² Parimal Mitra Smriti Mahavidyalaya, Department of Chemistry, Malbazar Jalpaiguri, West Bengal, India 735221.
³ Alipurduar University, Department of Chemistry, Alipurduar, West Bengal, India 736122.
⁴ University of North Bengal, Department of Biotechnology, Raja Rammohanpur, Darjeeling, West Bengal, India 734013.

Abstract

Our present study intended to investigate the encapsulation of DL-AGT within the lipophilic cavity of a β-CD molecule. The consequential inclusion system was characterized by UV-visible spectroscopy and ¹H NMR, PXRD, SEM, and FT-IR studies. Molecular docking was performed for the inclusion complex to discover the most proper orientation, and it was seen that the drug DL-AGT fits into the cavity of β-CD in a 1:1 ratio, which was also confirmed from the Job plot. Furthermore, a comparison was done on the basis of cell viability between the drug and its inclusion complex.