Ability of chloramphenicol to suppress phenotypically some bacterial mutations

Mol Gen Genet. 1978 Apr 17;160(3):319-24. doi: 10.1007/BF00332975.

Abstract

Chloramphenicol (CLP) at slightly inhibitory concentrations (3-5 microgram/ml) suppresses the inhibition of DNA synthesis and cell division caused by the temperature sensitive mutation dnaE486 at the nonpermissive temperature. Some other mutations can also be phenotypically suppressed by CLP. A similar effect is shown by chlortetracycline. Phenotypic suppression is caused by both these drugs in different cases than by streptomycin.

Publication types

  • Comparative Study

MeSH terms

  • Chloramphenicol / pharmacology*
  • Chlortetracycline / pharmacology
  • Dose-Response Relationship, Drug
  • Escherichia coli / drug effects
  • Escherichia coli / genetics
  • Mutation / drug effects*
  • Salmonella typhimurium / drug effects
  • Salmonella typhimurium / genetics
  • Streptomycin / pharmacology

Substances

  • Chloramphenicol
  • Chlortetracycline
  • Streptomycin