MRI Characteristics of Autoimmune Encephalitis With Autoantibodies to GABAA Receptor: A Case Series

Bo Deng; Mengfei Cai; Yue Qiu; Xiaoni Liu; Hai Yu; Xiang Zhang; Huifen Huang; Xiuhe Zhao; Wenbo Yang; Siqi Dong; Lei Jin; Shuguang Chu; Xiangjun Chen

doi:10.1212/NXI.0000000000001158

MRI Characteristics of Autoimmune Encephalitis With Autoantibodies to GABAA Receptor: A Case Series

Neurol Neuroimmunol Neuroinflamm. 2022 Mar 25;9(3):e1158. doi: 10.1212/NXI.0000000000001158. Print 2022 May.

Authors

Bo Deng¹, Mengfei Cai¹, Yue Qiu¹, Xiaoni Liu¹, Hai Yu¹, Xiang Zhang¹, Huifen Huang¹, Xiuhe Zhao¹, Wenbo Yang¹, Siqi Dong¹, Lei Jin¹, Shuguang Chu¹, Xiangjun Chen¹

Affiliation

¹ From the Department of Neurology (B.D., Y.Q., X.L., H.Y., X. Zhang, W.Y., S.D., L.J., X.C.), Huashan Hospital, Fudan University, Shanghai; National Center for Neurological Disorders (B.D., Y.Q., X.L., H.Y., X. Zhang, W.Y., S.D., L.J., X.C.), Shanghai, China; Department of Neurology (M.C.), Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands; Institute of Neurology (X.L., X. Zhang, X.C.), Fudan University, Shanghai; Department of Neurology (H.H.), Lishui Hospital, Zhejiang University School of Medicine; Department of Neurology (X. Zhao), Qilu Hospital, Shandong University, Jinan; Department of Radiology (S.C.), Shanghai East Hospital, Tongji University School of Medicine; and Human Phenome Institute (X.C.), Fudan University, Shanghai, China.

Abstract

Background and objectives: To characterize the clinical and neuroimaging phenotypes of patients with autoantibodies to γ-aminobutyric acid type A receptor (GABA_AR).

Methods: Ten patients with autoantibodies against GABA_AR from Huashan Hospital Autoimmune Encephalitis cohort were identified. We used MRI assessments and clinical examinations to summarize major clinical profile and visualize and quantify lesion distribution features. The relationship between clinical features, neuroimaging phenotypes, and topology of GABA_AR expression were further investigated.

Results: The median age at onset of 10 patients (8 male patients and 2 female patients) with anti-GABA_AR encephalitis was 41.5 years (range: 17-73 years). All patients had prominent seizures and multifocal spotted or confluent lesions involved in limbic, frontal, and temporal lobes on brain MRI. Bilateral but asymmetric lesions in cingulate gyri were observed in all patients. These involved lesions could change dynamically with immunotherapies and relapse. Distribution of patients' brain MRI lesions was positively correlated with gene expression level of β3 subunit-containing GABA_AR (Spearman ρ = 0.864, p = 0.001), the main target of autoantibodies. According to topology of lesions, patients with anti-GABA_AR encephalitis could be classified into 2 clinical-radiological types: confluent type with bilateral confluent lesions involved in almost all limbic, frontal, and temporal lobes and spotted type with multiple scattered small-to-medium patchy lesions. Patients with confluent type exhibited worse clinical presentations and outcomes when compared with those with spotted type (maximum modified Rankin scale [mRS]: 5 [5-5] vs 3.5 [3-4], respectively, p = 0.008; follow-up mRS: 4 [2-6] vs 0.5 [0-1], respectively, p = 0.016).

Discussion: Anti-GABA_AR encephalitis has distinctive neuroimaging phenotype. Cingulate gyri were frequently involved in this disorder. The topology of lesions might be associated with the distribution of β3 subunit-containing GABA_AR and reflected patients' disease severity and outcomes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Autoantibodies
Encephalitis*
Female
Hashimoto Disease*
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Receptors, GABA-A*
Young Adult
gamma-Aminobutyric Acid

Substances

Autoantibodies
Receptors, GABA-A
gamma-Aminobutyric Acid

Supplementary concepts

Hashimoto's encephalitis