Unilateral isolated optic nerve infiltration combined with central retinal artery occlusion in a patient with acute myeloid leukemia

Chen Zhao; Duo Wei; Xuan Shi; Mingwei Zhao

doi:10.1016/j.ajoc.2022.101493

Unilateral isolated optic nerve infiltration combined with central retinal artery occlusion in a patient with acute myeloid leukemia

Am J Ophthalmol Case Rep. 2022 Mar 16:26:101493. doi: 10.1016/j.ajoc.2022.101493. eCollection 2022 Jun.

Authors

Chen Zhao^{1

2

3

4

5}, Duo Wei^{1

2

3

4}, Xuan Shi^{1

2

3

4}, Mingwei Zhao^{1

2

3

4}

Affiliations

¹ Department of Ophthalmology, Peking University People's Hospital, Beijing, China.
² Eye Diseases and Optometry Institute, Beijing, China.
³ Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China.
⁴ College of Optometry, Peking University Health Science Center, Beijing, China.
⁵ Department of Ophthalmology, Air Force Medical Center, PLA, Beijing, China.

Abstract

Purpose: To report a case of unilateral isolated optic nerve infiltration combined with central retinal artery occlusion in a patient with acute myeloid leukemia.

Observations: A 28-year-old acute myeloid leukemia patient with systemic remission after hematopoietic stem cell transplantation presented with optic nerve infiltration combined with central retinal artery occlusion. Fundus examination showed diffuse papillary swelling with blurred margins and whitening macular with cherry-red spot. CBFβ-MYH11 fusion transcript analysis revealed central nervous system relapse of acute myeloid leukemia and optic nerve infiltration.

Conclusions and importance: Isolated optic nerve infiltration combined with central retinal artery occlusion is an extremely rare presentation in acute myeloid leukemia. Even in the absence of cytological and radiographic evidence from cerebrospinal fluid, optic nerve infiltration should not be ignored.

Keywords: Acute myeloid leukemia; Central retinal artery occlusion; Optic nerve infiltration.

Publication types

Case Reports