Azolium Aurates as Pre-Catalysts for the Oxidative Coupling of Terminal Alkynes under Mild Conditions

J Org Chem. 2022 Apr 1;87(7):4883-4893. doi: 10.1021/acs.joc.2c00237. Epub 2022 Mar 22.

Abstract

A simple and efficient method for the oxidative coupling of terminal alkynes is reported for the first time, making use of imidazol(in)ium aurates as pre-catalysts. This approach displays high functional group tolerance and leads to a broad range of 1,3-diyne compounds in moderate to excellent yields using low catalyst loading and is performed in air under mild and sustainable conditions.