Synthesis of carbon-11 radiolabelled transition metal complexes using 11C-dithiocarbamates

Sara Cesarec; Fraser Edgar; Titan Lai; Christophe Plisson; Andrew J P White; Philip W Miller

doi:10.1039/d2dt00266c

Synthesis of carbon-11 radiolabelled transition metal complexes using ¹¹C-dithiocarbamates

Dalton Trans. 2022 Mar 29;51(13):5004-5008. doi: 10.1039/d2dt00266c.

Authors

Sara Cesarec¹, Fraser Edgar^{1

2}, Titan Lai¹, Christophe Plisson³, Andrew J P White¹, Philip W Miller¹

Affiliations

¹ Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, Wood Lane, London, W12 OBZ, UK. philip.miller@imperial.ac.uk.
² School of Biomedical Engineering and Imaging Sciences, King's College London, 4th Floor Lambeth Wing, St Thomas' Hospital, London, UK.
³ Invicro, Burlington Danes Building, Hammersmith Hospital, Du Cane Road, London, UK.

PMID: 35293415
DOI: 10.1039/d2dt00266c

Abstract

A novel radiolabelling method exploiting ¹¹C-dithiocarbamate ligands has been used to generate ¹¹C-labelled Au(I), Au(III), Pd(II) and Pt(II) complexes in high radiochemical yields (71-99%). Labelled complexes were prepared in a rapid one-pot procedure via the substitution reaction of ¹¹C-dithiocarbamate ligands with appropriate transition metal chloride precursors.

MeSH terms

Carbon Radioisotopes
Coordination Complexes* / chemistry
Radiopharmaceuticals
Transition Elements* / chemistry

Substances

Carbon Radioisotopes
Carbon-11
Coordination Complexes
Radiopharmaceuticals
Transition Elements