Completed suicide is associated with a higher polygenic burden for psychiatric disorders

Marina Mitjans; Sergi Papiol; Carme Barrot; Maria Guardiola-Ripoll; Anna Giménez-Palomo; Patricia Gavín; Mojtaba Oraki Kohshour; Miriam Acosta; Edith Pomarol-Clotet; Josep Castellà-García; Rosa M Pérez-Pérez; Blanca Gutiérrez; Thomas G Schulze; Mar Fatjó-Vilas; Bárbara Arias; Antoni Benabarre

doi:10.1007/s00406-022-01398-5

Completed suicide is associated with a higher polygenic burden for psychiatric disorders

Eur Arch Psychiatry Clin Neurosci. 2022 Apr;272(3):355-358. doi: 10.1007/s00406-022-01398-5.

Authors

Marina Mitjans^#^{1

2

3}, Sergi Papiol^#^{4

5

6

7}, Carme Barrot⁸, Maria Guardiola-Ripoll^{5

9}, Anna Giménez-Palomo^{10

11}, Patricia Gavín¹⁰, Mojtaba Oraki Kohshour^{6

12}, Miriam Acosta¹³, Edith Pomarol-Clotet^{5

9}, Josep Castellà-García¹⁴, Rosa M Pérez-Pérez¹⁵, Blanca Gutiérrez¹⁶, Thomas G Schulze^{6

17

18}, Mar Fatjó-Vilas^{5

9

13}, Bárbara Arias^#^{4

5

13}, Antoni Benabarre^#^{5

10

11

19}

Affiliations

¹ Department of Genetics, Microbiology and Statistics, Faculty of Biology, University of Barcelona, Av. Diagonal 645, 08028, Barcelona, Spain. marina.mitjans@ub.edu.
² Biomedicine Institute of the University of Barcelona (IBUB), Barcelona, Spain. marina.mitjans@ub.edu.
³ Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain. marina.mitjans@ub.edu.
⁴ Biomedicine Institute of the University of Barcelona (IBUB), Barcelona, Spain.
⁵ Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
⁶ Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
⁷ Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
⁸ Forensic Genetic Laboratory, University of Barcelona, Barcelona, Spain.
⁹ FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
¹⁰ Bipolar and Depressive Disorders Unit, Psychiatry and Psychology Service, Clinical Institute of Neuroscience. Hospital Clinic de Barcelona, Barcelona, Spain.
¹¹ Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.
¹² Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
¹³ Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain.
¹⁴ Servei de Patologia Forense, Institut de Medicina Legal i Ciències Forenses de Catalunya, Barcelona, Spain.
¹⁵ Divisió de Lleida, Institut de Medicina Legal i Ciències Forenses de Catalunya, Barcelona, Spain.
¹⁶ Department Psychiatry and Institute of Neurosciences (Biomedical Research Center), University of Granada, Granada, Spain.
¹⁷ Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.
¹⁸ Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
¹⁹ Department of Medicine, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.

^# Contributed equally.

PMID: 35284949
DOI: 10.1007/s00406-022-01398-5

No abstract available

Keywords: Bipolar disorder; Completed suicide; Major depressive disorder; Polygenic risk score; Schizophrenia; Suicide attempt.

Publication types

Editorial

MeSH terms

Humans
Mental Disorders* / genetics
Multifactorial Inheritance / genetics
Risk Factors
Suicide* / psychology
Suicide, Completed*