Gut and Vaginal Microbiomes in PCOS: Implications for Women's Health

Yuanyuan Gu; Guannan Zhou; Fangyue Zhou; Yao Li; Qiongwei Wu; Hongyu He; Yi Zhang; Chengbin Ma; Jingxin Ding; Keqin Hua

doi:10.3389/fendo.2022.808508

Gut and Vaginal Microbiomes in PCOS: Implications for Women's Health

Front Endocrinol (Lausanne). 2022 Feb 23:13:808508. doi: 10.3389/fendo.2022.808508. eCollection 2022.

Authors

Yuanyuan Gu^{1

2}, Guannan Zhou^{2

3}, Fangyue Zhou⁴, Yao Li⁵, Qiongwei Wu¹, Hongyu He⁶, Yi Zhang¹, Chengbin Ma¹, Jingxin Ding^{2

3}, Keqin Hua^{2

3}

Affiliations

¹ Changning Maternity and Infant Health Hospital, East China Normal University, Shanghai, China.
² Department of Gynecology, The Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
³ Department of Gynecology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China.
⁴ The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
⁵ Department of Urology, Gongli Hospital of Shanghai Pudong New Area, Shanghai, China.
⁶ Department of Intensive Care Unit, Zhongshan Hospital, Fudan University, Shanghai, China.

Abstract

PCOS is defined as a kind of endocrine and metabolic disorder which affects females at reproductive ages, is becoming much more common, nowadays. Microbiomes are known as microorganisms that inhabit the body to play a vital role in human health. In recent years, several basic and clinical studies have tried to investigate the correlation between the reproductive health/disorder and microbiomes (gut microbiomes and vaginal microbiomes). However, the mechanism is still unclear. In this review, we reviewed the relationship between PCOS and microbiomes, including gut/vaginal microbiomes compositions in PCOS, mechanism of microbiomes and PCOS, and then collectively focused on the recent findings on the influence of microbiomes on the novel insight regarding the therapeutic strategies for PCOS in the future clinical practice.

Keywords: PCOS (polycystic ovarian syndrome); gut microbiomes; mechanism; therapeutics; vaginal microbiomes.

Publication types

Review

MeSH terms

Female
Gastrointestinal Microbiome*
Humans
Microbiota*
Polycystic Ovary Syndrome* / metabolism
Reproduction
Women's Health