Emerging Roles and Mechanisms of lncRNA FOXD3-AS1 in Human Diseases

Qinfan Yao; Xiuyuan Zhang; Dajin Chen

doi:10.3389/fonc.2022.848296

Emerging Roles and Mechanisms of lncRNA FOXD3-AS1 in Human Diseases

Front Oncol. 2022 Feb 25:12:848296. doi: 10.3389/fonc.2022.848296. eCollection 2022.

Authors

Qinfan Yao^{1

2

3

4}, Xiuyuan Zhang^{1

2

3

4}, Dajin Chen^{1

2

3

4}

Affiliations

¹ Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
² Key Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, China.
³ National Key Clinical Department of Kidney Diseases, Institute of Nephrology, Zhejiang University, Hangzhou, China.
⁴ Zhejiang Clinical Research Center of Kidney and Urinary System Disease, Hangzhou, China.

Abstract

Numerous long noncoding RNAs (lncRNAs) have been identified as powerful regulators of human diseases. The lncRNA FOXD3-AS1 is a novel lncRNA that was recently shown to exert imperative roles in the initialization and progression of several diseases. Emerging studies have shown aberrant expression of FOXD3-AS1 and close correlation with pathophysiological traits of numerous diseases, particularly cancers. More importantly, FOXD3-AS1 was also found to ubiquitously impact a range of biological functions. This study aims to summarize the expression, associated clinicopathological features, major functions and molecular mechanisms of FOXD3-AS1 in human diseases and to explore its possible clinical applications.

Keywords: FOXD3-AS1; clinicopathological feature; function; long noncoding RNA; mechanism.

Publication types

Review