COVID-19 susceptibility and vaccination coverage for measles, rubella and mumps in students and healthcare workers in Trieste hospitals (NE Italy)

Eleonora Cattaruzza; Lucia Radillo; Federico Ronchese; Corrado Negro; Francesca Rui; Paola De Michieli; Francesca Larese Filon

doi:10.1016/j.jvacx.2022.100147

COVID-19 susceptibility and vaccination coverage for measles, rubella and mumps in students and healthcare workers in Trieste hospitals (NE Italy)

Vaccine X. 2022 Feb 25:10:100147. doi: 10.1016/j.jvacx.2022.100147. eCollection 2022 Apr.

Authors

Eleonora Cattaruzza^{1

2}, Lucia Radillo^{1

2}, Federico Ronchese^{1

2}, Corrado Negro^{1

2}, Francesca Rui^{1

2}, Paola De Michieli^{1

2}, Francesca Larese Filon^{1

2}

Affiliations

¹ Scuola di Specializzazione in Medicina del Lavoro, Università di Trieste.
² Unità Clinica di Medicina del Lavoro, Università di Trieste, Azienda Sanitaria Universitaria Integrata di Trieste, Italy.

Abstract

Background: Measles, mumps, and rubella (MMR) vaccines have been suggested as preventive measures to protect subjects from the worst sequelae of COVID-19 infection because neutralizing antibodies can cross-react with other viruses.

Aim: To verify COVID-19 infection in MMR vaccinated and non-vaccinated healthcare workers and medical students in Trieste Hospitals.

Results: Nurse aids resulted in significantly more infections than structured physicians (OR 1.80; 95% CI 1.14-2.80) while students resulted in less infections (OR, 0.66; 95% CI 0.43-1.01). The presence of an MMR vaccination was inversely associated with COVID-19 (OR, 0.77; 95% CI 0.61-0.96) but only in univariate analysis. In the multivariable logistic regression analysis, MMR vaccination lost statistical significance (OR, 0.86; 95%CI 0.62-1.20).On 13 HCWs hospitalized for COVID-19, 11 resulted not vaccinated for MMR.

Discussion: Our study found a mild, non-significant reduction in SARS-CoV-2 infections in workers vaccinated with MMR.