Very early-onset inflammatory bowel disease: Novel description in glycogen storage disease type Ia

William B Hannah; Ricardo C Ong; Margarita Nieto Moreno; Surekha Pendyal; Monica Abdelmalak; Judith Kelsen; Nancy M McGreal; Priya S Kishnani

doi:10.1016/j.ymgmr.2022.100848

Very early-onset inflammatory bowel disease: Novel description in glycogen storage disease type Ia

Mol Genet Metab Rep. 2022 Feb 15:31:100848. doi: 10.1016/j.ymgmr.2022.100848. eCollection 2022 Jun.

Authors

William B Hannah¹, Ricardo C Ong¹, Margarita Nieto Moreno¹, Surekha Pendyal¹, Monica Abdelmalak², Judith Kelsen³, Nancy M McGreal¹, Priya S Kishnani¹

Affiliations

¹ Department of Pediatrics, Duke University Medical Center, United States of America.
² Department of Pathology, Duke University Medical Center, United States of America.
³ Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, United States of America.

Abstract

Although inflammatory bowel disease is a well-described feature of glycogen storage disease type Ib, it has been reported in only a small number of individuals with glycogen storage disease type Ia (GSDIa). We describe, to our knowledge, the first patient with GSDIa and very early-onset inflammatory bowel disease (VEO-IBD). Larger studies are needed to better understand this possible association, elucidate the mechanism of VEO-IBD in GSDIa, and inform management.

Keywords: Glycogen storage disease type 1a; Very early-onset inflammatory bowel.

Publication types

Case Reports