Orchestration of Ion Channels and Transporters in Neocortical Development and Neurological Disorders

Yuki Bando; Masaru Ishibashi; Satoru Yamagishi; Atsuo Fukuda; Kohji Sato

doi:10.3389/fnins.2022.827284

Orchestration of Ion Channels and Transporters in Neocortical Development and Neurological Disorders

Front Neurosci. 2022 Feb 14:16:827284. doi: 10.3389/fnins.2022.827284. eCollection 2022.

Authors

Yuki Bando¹, Masaru Ishibashi², Satoru Yamagishi¹, Atsuo Fukuda², Kohji Sato¹

Affiliations

¹ Department of Organ and Tissue Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan.
² Department of Neurophysiology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Abstract

Electrical activity plays crucial roles in neural circuit formation and remodeling. During neocortical development, neurons are generated in the ventricular zone, migrate to their correct position, elongate dendrites and axons, and form synapses. In this review, we summarize the functions of ion channels and transporters in neocortical development. Next, we discuss links between neurological disorders caused by dysfunction of ion channels (channelopathies) and neocortical development. Finally, we introduce emerging optical techniques with potential applications in physiological studies of neocortical development and the pathophysiology of channelopathies.

Keywords: axon; cerebral cortex; channelopathy; dendrite; ion channel; neurogenesis; neuronal migration; transporter.

Publication types

Review