Cytomegalovirus Infection Is Associated With Increased Prevalence of Latent Tuberculosis Infection

Yuri F van der Heijden; Bin Zhang; Claire A Chougnet; Moises A Huaman

doi:10.1093/ofid/ofab539

Cytomegalovirus Infection Is Associated With Increased Prevalence of Latent Tuberculosis Infection

Open Forum Infect Dis. 2021 Oct 23;8(11):ofab539. doi: 10.1093/ofid/ofab539. eCollection 2021 Nov.

Authors

Yuri F van der Heijden¹, Bin Zhang², Claire A Chougnet³, Moises A Huaman⁴

Affiliations

¹ Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
² Division of Biostatistics and Epidemiology, Cincinnati Children's Medical Center, Cincinnati, Ohio, USA.
³ Division of Immunobiology, Cincinnati Children's Medical Center, Cincinnati, Ohio, USA.
⁴ Vanderbilt Tuberculosis Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

Abstract

Cytomegalovirus (CMV) increases tuberculosis (TB) risk, but its relationship with latent TB infection (LTBI) is unknown. Using US nationally representative data, we report that CMV was independently associated with LTBI (odds ratio, 2.94; 95% CI, 1.19-7.28; P=.02). CMV and LTBI were associated with higher C-reactive protein, suggesting chronic inflammation.

Keywords: cytomegalovirus; immune dysregulation; inflammation; latent tuberculosis infection.

Grants and funding

K08 AI106420/AI/NIAID NIH HHS/United States