Circ_0020123 promotes NSCLC tumorigenesis via up-regulating KIAA1522 expression through miR-940

Cell Cycle. 2022 May;21(9):894-907. doi: 10.1080/15384101.2022.2034093. Epub 2022 Feb 23.

Abstract

Circ_0020123 was highly expressed in NSCLC tissues and cell lines, and knockdown of circ_0020123 abolished cell growth, migration and invasion in vitro and hindered tumor growth in nude mice. Mechanically, circ_0020123 directly targeted miR-940, and KIAA1522 was a target of miR-940. Thereafter, a series of rescue experiments showed that circ_0020123 served its biological functions by miR-940/KIAA1522 axis. In all, circ_0020123 acted as an oncogene to promote the tumorigenesis of NSCLC via miR-940/KIAA1522 axis, suggesting a potential therapeutic target for NSCLC treatment.

Keywords: KIAA1522; NSCLC; circ_0020123; miR-940; tumorigenesis.

MeSH terms

  • Animals
  • Carcinogenesis / genetics
  • Carcinoma, Non-Small-Cell Lung* / metabolism
  • Cell Line, Tumor
  • Cell Proliferation / genetics
  • Cell Transformation, Neoplastic
  • Lung Neoplasms* / metabolism
  • Mice
  • Mice, Nude
  • MicroRNAs* / genetics
  • MicroRNAs* / metabolism
  • RNA, Circular / genetics

Substances

  • MicroRNAs
  • RNA, Circular

Grants and funding

The author(s) reported there is no funding associated with the work featured in this article.