Treatment-induced neuropathy of diabetes in an adolescent with rapid reduction in HbA1c and weight loss: Persistent neuropathic findings at follow-up after 1.5 years

Vinni Faber Rasmussen; Mathilde Thrysøe; Hatice Tankisi; Páll Karlsson; Esben Thyssen Vestergaard; Kurt Kristensen; Jens Randel Nyengaard; Klaus Krogh; Christina Brock; Astrid Juhl Terkelsen

doi:10.1002/ccr3.5415

Treatment-induced neuropathy of diabetes in an adolescent with rapid reduction in HbA1c and weight loss: Persistent neuropathic findings at follow-up after 1.5 years

Clin Case Rep. 2022 Feb 10;10(2):e05415. doi: 10.1002/ccr3.5415. eCollection 2022 Feb.

Authors

Vinni Faber Rasmussen^{1

2}, Mathilde Thrysøe¹, Hatice Tankisi³, Páll Karlsson^{1

4}, Esben Thyssen Vestergaard^{2

5}, Kurt Kristensen⁵, Jens Randel Nyengaard^{4

6}, Klaus Krogh^{5

7}, Christina Brock⁸, Astrid Juhl Terkelsen^{1

9}

Affiliations

¹ Danish Pain Research Center Department of Clinical Medicine Aarhus University Aarhus Denmark.
² Department of Pediatrics and Adolescents Randers Regional Hospital Randers Denmark.
³ Department of Neurophysiology Department of Clinical Medicine Aarhus University Aarhus Denmark.
⁴ Core Centre for Molecular Morphology Section for Stereology and Microscopy Department of Clinical Medicine Aarhus University Aarhus Denmark.
⁵ Steno Diabetes Center Aarhus Aarhus University Hospital Aarhus Denmark.
⁶ Department of Pathology Aarhus University Hospital Aarhus Denmark.
⁷ Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark.
⁸ Department of Gastroenterology Aalborg University Hospital Aalborg Denmark.
⁹ Department of Neurology Aarhus University Hospital Aarhus Denmark.

Abstract

Treatment-induced neuropathy of diabetes (TIND) is a condition occurring within weeks after a rapid decline in blood glucose. This case report illustrates consequences in an adolescent with TIND. Gold standard methods diagnosing large fiber, small fiber, and autonomic neuropathy were abnormal at 1.5 years of follow-up. Awareness of TIND is important.

Keywords: adolescent; neuropathy; pediatric; treatment‐induced neuropathy of diabetes; type 1 diabetes.

Publication types

Case Reports