Interprofessional Consensus Regarding Design Requirements for Liquid-Based Perinatal Life Support (PLS) Technology

M Beatrijs van der Hout-van der Jagt; E J T Verweij; Peter Andriessen; Willem P de Boode; Arend F Bos; Frank L M Delbressine; Alex J Eggink; Jan Jaap H M Erwich; Loe M G Feijs; Floris Groenendaal; Boris W W Kramer; A Titia Lely; Rachel F A M Loop; Franziska Neukamp; Wes Onland; Martijn A Oudijk; Arjan B Te Pas; Irwin K M Reiss; Mark Schoberer; Ralph R Scholten; Marc E A Spaanderman; Myrthe van der Ven; Marijn J Vermeulen; Frans N van de Vosse; S Guid Oei

doi:10.3389/fped.2021.793531

Interprofessional Consensus Regarding Design Requirements for Liquid-Based Perinatal Life Support (PLS) Technology

Front Pediatr. 2022 Jan 19:9:793531. doi: 10.3389/fped.2021.793531. eCollection 2021.

Authors

M Beatrijs van der Hout-van der Jagt^{1

2

3}, E J T Verweij⁴, Peter Andriessen^{5

6}, Willem P de Boode⁷, Arend F Bos⁸, Frank L M Delbressine⁹, Alex J Eggink¹⁰, Jan Jaap H M Erwich¹¹, Loe M G Feijs⁹, Floris Groenendaal¹², Boris W W Kramer¹³, A Titia Lely¹⁴, Rachel F A M Loop^{2

9}, Franziska Neukamp¹⁵, Wes Onland¹⁶, Martijn A Oudijk¹⁷, Arjan B Te Pas¹⁸, Irwin K M Reiss¹⁹, Mark Schoberer¹⁵, Ralph R Scholten²⁰, Marc E A Spaanderman^{20

21}, Myrthe van der Ven^{1

3}, Marijn J Vermeulen^{19

22}, Frans N van de Vosse², S Guid Oei^{1

3}

Affiliations

¹ Department of Obstetrics and Gynecology, Máxima Medical Centre, Veldhoven, Netherlands.
² Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.
³ Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.
⁴ Department of Obstetrics and Gynecology, Division of Fetal Therapy, Leiden University Medical Center (LUMC), Leiden, Netherlands.
⁵ Department of Neonatology, Máxima Medical Centre, Veldhoven, Netherlands.
⁶ Department of Applied Physics, School of Medical Physics and Engineering Eindhoven, Eindhoven University of Technology, Eindhoven, Netherlands.
⁷ Division of Neonatology, Department of Perinatology, Radboud University Medical Center, Radboud Institute for Health Sciences, Amalia Children's Hospital, Nijmegen, Netherlands.
⁸ Department of Neonatology, University Medical Center Groningen, University of Groningen, Beatrix Children's Hospital, Groningen, Netherlands.
⁹ Department of Industrial Design Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.
¹⁰ Department of Obstetrics and Gynecology, Erasmus Medical Centre, Rotterdam, Netherlands.
¹¹ Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
¹² Department of Neonatology, Utrecht University Medical Center, Utrecht, Netherlands.
¹³ Department of Neonatology, Maastricht University Medical Center (MUMC), Maastricht, Netherlands.
¹⁴ Department of Obstetrics and Gynecology, Utrecht University Medical Center, Utrecht, Netherlands.
¹⁵ Institute for Applied Medical Engineering and Clinic for Neonatology, University Hospital Aachen, Aachen, Germany.
¹⁶ Department of Neonatology, Amsterdam UMC, Amsterdam, Netherlands.
¹⁷ Amsterdam Reproduction and Development Research Institute, Department of Obstetrics, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
¹⁸ Department of Neonatology, Leiden University Medical Center (LUMC), Leiden, Netherlands.
¹⁹ Department of Neonatology, Erasmus Medical Centre, Rotterdam, Netherlands.
²⁰ Department of Obstetrics and Gynecology, Radboud Medical Centre, Nijmegen, Netherlands.
²¹ Department of Obstetrics and Gynecology, Maastricht University Medical Center (MUMC), Maastricht, Netherlands.
²² Care4Neo Foundation, Rotterdam, Netherlands.

Abstract

Liquid-based perinatal life support (PLS) technology will probably be applied in a first-in-human study within the next decade. Research and development of PLS technology should not only address technical issues, but also consider socio-ethical and legal aspects, its application area, and the corresponding design implications. This paper represents the consensus opinion of a group of healthcare professionals, designers, ethicists, researchers and patient representatives, who have expertise in tertiary obstetric and neonatal care, bio-ethics, experimental perinatal animal models for physiologic research, biomedical modeling, monitoring, and design. The aim of this paper is to provide a framework for research and development of PLS technology. These requirements are considering the possible respective user perspectives, with the aim to co-create a PLS system that facilitates physiological growth and development for extremely preterm born infants.

Keywords: AAPT; artificial placenta; design implications; perinatal life support; user perspectives; value-sensitive design.

Copyright © 2022 van der Hout-van der Jagt, Verweij, Andriessen, de Boode, Bos, Delbressine, Eggink, Erwich, Feijs, Groenendaal, Kramer, Lely, Loop, Neukamp, Onland, Oudijk, te Pas, Reiss, Schoberer, Scholten, Spaanderman, van der Ven, Vermeulen, van de Vosse and Oei.