Fatal SARS-CoV-2-Associated Panton-Valentine Leukocidin-producing Staphylococcal Bacteremia: A Nationwide Multicenter Cohort Study

Pediatr Infect Dis J. 2022 Apr 1;41(4):e142-e145. doi: 10.1097/INF.0000000000003476.

Abstract

We reviewed all cases of Panton-Valentine leukocidin-producing Staphylococcus aureus (PVL-SA) bacteremia in Danish children between 2016 and 2021. We found 2 fatal cases with preceding viral prodrome due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Given the usual benign course of SARS-CoV-2 infection in children, awareness of possible superinfection with PVL-SA in a child with rapid deterioration is crucial to ensure adequate treatment, including antimicrobial drugs with antitoxin effect.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Bacteremia*
  • Bacterial Toxins / biosynthesis*
  • COVID-19 / complications*
  • COVID-19 / virology
  • Child
  • Child, Preschool
  • Coinfection
  • Comorbidity
  • Denmark / epidemiology
  • Exotoxins / biosynthesis*
  • Female
  • Humans
  • Infant
  • Leukocidins / biosynthesis*
  • Male
  • Methicillin-Resistant Staphylococcus aureus / genetics
  • Methicillin-Resistant Staphylococcus aureus / metabolism
  • Public Health Surveillance
  • SARS-CoV-2*
  • Severity of Illness Index
  • Staphylococcal Infections / diagnosis
  • Staphylococcal Infections / etiology*
  • Staphylococcal Infections / mortality*
  • Staphylococcal Infections / therapy
  • Staphylococcus aureus / drug effects
  • Staphylococcus aureus / genetics*
  • Staphylococcus aureus / metabolism

Substances

  • Bacterial Toxins
  • Exotoxins
  • Leukocidins
  • Panton-Valentine leukocidin