Biocompatibility of NbTaTiVZr with Surface Modifications for Osteoblasts

Shih-Jie Lin; Jia-An Lin; Wei Yu; Chanho Lee; Chun-Yu Hung; Jonathan D Poplawsky; Peter K Liaw; Yi-Chia Chou

doi:10.1021/acsabm.1c01103

Biocompatibility of NbTaTiVZr with Surface Modifications for Osteoblasts

ACS Appl Bio Mater. 2022 Feb 21;5(2):642-649. doi: 10.1021/acsabm.1c01103. Epub 2022 Jan 26.

Authors

Shih-Jie Lin^{1

2

3}, Jia-An Lin⁴, Wei Yu⁴, Chanho Lee^{5

6}, Chun-Yu Hung⁷, Jonathan D Poplawsky⁸, Peter K Liaw⁵, Yi-Chia Chou^{4

9}

Affiliations

¹ Department of Orthopaedic Surgery, New Taipei Municipal TuCheng Hospital, Chang Gung Memorial Hospital, New Taipei City 23653, Taiwan.
² Bone and Joint Research Center, Chang Gung Memorial Hospital, Linkou 33305, Taiwan.
³ Department of Chemical Engineering, National Tsing Hua University, Hsinchu 30010, Taiwan.
⁴ Department of Electrophysics, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan.
⁵ Department of Materials Science and Engineering, The University of Tennessee, Knoxville, Tennessee 37996-2100, United States.
⁶ Materials Science and Technology Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States.
⁷ Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Yunlin 63863, Taiwan.
⁸ Center for Nanophases Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.
⁹ Department of Materials Science and Engineering, National Taiwan University, Taipei 10617, Taiwan.

PMID: 35080840
DOI: 10.1021/acsabm.1c01103

Abstract

We report a potential biomedical material, NbTaTiVZr, and the impact of surface roughness on the osteoblast culture and later behavior based on in vitro tests of preosteoblasts. Cell activities such as adhesion, viability, and typical protein activity on NbTaTiVZr showed comparable results with that of commercially pure Ti (CP-Ti). In addition, NbTaTiVZr with a smooth surface exhibits better cell adhesion, viability, and typical protein activity which shows that surface modification can improve the biocompatibility of NbTaTiVZr. This supports the biological evidence and shows that NbTaTiVZr can potentially be evaluated as a biomedical material for clinical use.

Keywords: NbTaTiVZr; biocompatibility; biomedical material; in vitro test; surface modification.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Biocompatible Materials / metabolism
Cell Adhesion
Osteoblasts*
Surface Properties
Titanium* / pharmacology

Substances

Biocompatible Materials
Titanium