Associations of lipoprotein particle profile and objectively measured physical activity and sedentary time in schoolchildren: a prospective cohort study

Paul Remy Jones; Tarja Rajalahti; Geir Kåre Resaland; Eivind Aadland; Jostein Steene-Johannessen; Sigmund Alfred Anderssen; Tone Frost Bathen; Trygve Andreassen; Olav Martin Kvalheim; Ulf Ekelund

doi:10.1186/s12966-022-01244-w

Associations of lipoprotein particle profile and objectively measured physical activity and sedentary time in schoolchildren: a prospective cohort study

Int J Behav Nutr Phys Act. 2022 Jan 21;19(1):5. doi: 10.1186/s12966-022-01244-w.

Authors

Affiliations

¹ Department of Sports Medicine, Norwegian School of Sport Sciences, Ullevål Stadion, Post Box 4014, 0806, Oslo, Norway. paulj@nih.no.
² Department of Chemistry, University of Bergen, Bergen, Norway.
³ Førde Health Trust, Førde, Norway.
⁴ Center for Physically Active Learning, Faculty of Education, Arts and Sports, Campus Sogndal, Western Norway University of Applied Sciences, Sogndal, Norway.
⁵ Department of Sport, Food and Natural Sciences, Western Norway University of Applied Sciences, Sogndal, Norway.
⁶ Department of Sports Medicine, Norwegian School of Sport Sciences, Ullevål Stadion, Post Box 4014, 0806, Oslo, Norway.
⁷ Department of Circulation and Medical Imaging, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
⁸ MR Core Facility, Department of Circulation and Medical Imaging, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.

Abstract

Background: Our understanding of the mechanisms through which physical activity might benefit lipoprotein metabolism is inadequate. Here we characterise the continuous associations between physical activity of different intensities, sedentary time, and a comprehensive lipoprotein particle profile.

Methods: Our cohort included 762 fifth grade (mean [SD] age = 10.0 [0.3] y) Norwegian schoolchildren (49.6% girls) measured on two separate occasions across one school year. We used targeted proton nuclear magnetic resonance (¹H NMR) spectroscopy to produce 57 lipoprotein measures from fasted blood serum samples. The children wore accelerometers for seven consecutive days to record time spent in light-, moderate-, and vigorous-intensity physical activity, and sedentary time. We used separate multivariable linear regression models to analyse associations between the device-measured activity variables-modelled both prospectively (baseline value) and as change scores (follow-up minus baseline value)-and each lipoprotein measure at follow-up.

Results: Higher baseline levels of moderate-intensity and vigorous-intensity physical activity were associated with a favourable lipoprotein particle profile at follow-up. The strongest associations were with the larger subclasses of triglyceride-rich lipoproteins. Sedentary time was associated with an unfavourable lipoprotein particle profile, the pattern of associations being the inverse of those in the moderate-intensity and vigorous-intensity physical activity analyses. The associations with light-intensity physical activity were more modest; those of the change models were weak.

Conclusion: We provide evidence of a prospective association between time spent active or sedentary and lipoprotein metabolism in schoolchildren. Change in activity levels across the school year is of limited influence in our young, healthy cohort.

Trial registration: ClinicalTrials.gov , # NCT02132494 . Registered 7th April 2014.

Keywords: Epidemiology; Lipoproteins; Metabolism; Physical activity; Sedentary time.

Publication types

Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Accelerometry* / methods
Child
Cohort Studies
Exercise
Female
Humans
Lipoproteins
Male
Prospective Studies
Sedentary Behavior*

Substances

Lipoproteins

Associated data

ClinicalTrials.gov/NCT02132494