Atomically precise metal nanoclusters with specific chemical compositions have become a popular research topic due to their precise structures, attractive properties, and wide range of applications in various fields. Currently, among more than 100 reported metal nanoclusters with precise formulas, 38-atom coinage metal nanoclusters stand out due to their unique structural diversities, such as face-centered cubic (FCC) and body-centered cubic (BCC) arrangements. Among them, the formation of the metal cores includes vertex-sharing, face-fusion, and FCC cubes fusion. Due to their geometrical features, 38-atom coinage metal nanoclusters exhibit attractive properties, making them an ideal model for exploring structure-property relationships. Therefore, 38-atom coinage metal nanoclusters are a universal key to the treasure trove of nanoclusters, which can open almost all fields and are of great research significance. This paper focuses on the structure of 38-atom coinage metal nanoclusters and reviews the preparation and crystallization methods, excellent properties, and practical applications. Finally, future research prospects and development opportunities are provided.