Neutrophil Gelatinase-associated Lipocalin (NGAL) as a Marker of Renal Tubular Injury in Metabolic Syndrome Patients with Hyperuricemia

J Assoc Physicians India. 2022 Dec;69(12):11-12.

Abstract

Background: Hyperuricemia has been associated with chronic kidney disease, evidence suggests that hyperuricemiamight plays a role in progression of renal damage. Whether hyperuricemia can lead to renal tubular injury remains unclear. In this study we aimed to determine serum NGAL and urinary NGAL/creatinine ratio as markers of reanal tubular injury in metabolic syndrome patientshave hyper or normouricemia.

Material and methods: In this hospital based cross- sectional study,180 par ticipants with metabolic syndrome were included,90 patients had hyperuricemia and 90 were with normouricemia. Clinical biochemical parameters of serum NGAL and urinary NGAL were measured using a commercially available enzyme-linked immunosorbent assay (ELISA) kit. Receiver operating characteristic(ROC) curve was analysis was employed to assess the sensitivity and specificity of serum NGAL and urine NGAL/creatinine ratio.

Results: Out of all, 96 were males and 84 were females. The mean age of participants was 45 ± 7 years. Serum NGAL levels and Urinary NGAL/creatinine ratio were higher in metabolic syndrome patients with hyperuricemia. High Serum NGAL was positively correlated with presence of hypertension; HbA1c and waist-hip ratio and negatively correlated with HDL.

Conclusion: Serum NGAL levels and urinary NGAL/creatinine ratio were higher in metabolic syndrome patients with hyperuricemia that indicates presence of renal tubular injury in these patients. High Serum NGAL was positively correlated with presence of hypertension; HbA1c and waist-hip ratio.

MeSH terms

  • Acute-Phase Proteins
  • Adult
  • Female
  • Humans
  • Hyperuricemia* / diagnosis
  • Lipocalin-2
  • Lipocalins
  • Male
  • Metabolic Syndrome* / complications
  • Metabolic Syndrome* / diagnosis
  • Middle Aged
  • Proto-Oncogene Proteins

Substances

  • Acute-Phase Proteins
  • Lipocalin-2
  • Lipocalins
  • Proto-Oncogene Proteins