Preoperative Prophylactic Antibiotics in Total Hip and Knee Arthroplasty: What, When, and How

J Arthroplasty. 2022 Aug;37(8):1432-1434. doi: 10.1016/j.arth.2022.01.019. Epub 2022 Jan 17.

Abstract

Although there are numerous nonpatient-related factors that may help reduce infection risk, the proper use of prophylactic antibiotics is most responsible for reducing infection. The role of prophylactic antibiotics is to reduce early periprosthetic joint replacement, which is accomplished by having adequate antibiotic tissue levels at the time of skin incision. The goal of this section of the symposium is to review current antibiotic recommendations, how to manage patients with a self-reported penicillin allergy, review the use of dual antibiotics, discuss the use of antibiotics in the outpatient total joint setting, as well as very briefly discuss the administration of intraosseous antibiotics in knee arthroplasty.

Keywords: hip and knee arthroplasty; management of patients with penicillin allergy; periprosthetic infection; prophylactic antibiotics; prophylactic antibiotics in outpatient total joint replacement.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Antibiotic Prophylaxis
  • Arthroplasty, Replacement, Hip* / adverse effects
  • Arthroplasty, Replacement, Knee* / adverse effects
  • Humans
  • Prosthesis-Related Infections* / drug therapy
  • Prosthesis-Related Infections* / prevention & control
  • Retrospective Studies

Substances

  • Anti-Bacterial Agents