Profound thrombocytopenia associated with administration of multiple anti-inflammatory agents in baboons

Mohamed H Bikhet; Christophe Hansen-Estruch; Mariyam Javed; Dalis E Collins; Jeremy B Foote; David Ayares; Hidetaka Hara; David K C Cooper

doi:10.1002/iid3.588

Profound thrombocytopenia associated with administration of multiple anti-inflammatory agents in baboons

Immun Inflamm Dis. 2022 Mar;10(3):e588. doi: 10.1002/iid3.588. Epub 2022 Jan 20.

Authors

Mohamed H Bikhet¹, Christophe Hansen-Estruch¹, Mariyam Javed¹, Dalis E Collins², Jeremy B Foote³, David Ayares⁴, Hidetaka Hara¹, David K C Cooper¹

Affiliations

¹ Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
² Animal Resources Program, University of at Birmingham, Birmingham, Alabama, USA.
³ Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
⁴ Revivicor, Blacksburg, Virginia, USA.

Abstract

Congestion, granular platelet debris both within macrophage and extracellularly, and neutrophil infiltration in the spleen of a baboon that was euthanized with profound thrombocytopenia.

Keywords: IL-6; baboon; pig; thrombocytopenia; xenotransplantation.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Animals, Genetically Modified
Anti-Inflammatory Agents / therapeutic use
Papio
Thrombocytopenia* / drug therapy
Transplantation, Heterologous

Substances

Anti-Inflammatory Agents

Grants and funding

U19 AI090959/AI/NIAID NIH HHS/United States