Single nucleosome tracking to study chromatin plasticity

Melike Lakadamyali

doi:10.1016/j.ceb.2021.12.005

Single nucleosome tracking to study chromatin plasticity

Curr Opin Cell Biol. 2022 Feb:74:23-28. doi: 10.1016/j.ceb.2021.12.005. Epub 2022 Jan 13.

Author

Melike Lakadamyali¹

Affiliation

¹ Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: melikel@pennmedicine.upenn.edu.

Abstract

The dynamic spatial organization of chromatin within the nucleus is emerging as a key regulator of gene activity and cell phenotype. This review will focus on single molecule tracking as an enabling tool to study chromatin dynamics at the level of individual nucleosomes.

Publication types

Review
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural

MeSH terms

Cell Nucleus
Chromatin Assembly and Disassembly
Chromatin* / genetics
Nucleosomes* / genetics
Single Molecule Imaging

Substances

Chromatin
Nucleosomes

Abstract

Publication types

MeSH terms

Substances

Grants and funding